GLPBio

SMARCA2-IN-10

Catalog No.: GC81479Purity:>96.00%
COASDSData Sheet
SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor ( IC50 =17.676 μM).

製品は研究用途にのみ使用できます。人体には使用できません。患者への販売は行っておりません。

SMARCA2-IN-10
Cas No.: 82131-85-9
10mM (in 1mL DMSO)In Stock
$82.00
1
5mgIn Stock
$75.00
1
10mgIn Stock
$120.00
1
25mgIn Stock
$239.00
1
50mgIn Stock
$383.00
1
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引用文献 (Citations)

現在、この製品の引用文献はありません。以下はGlpBio製品を引用した代表的な文献です。
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

製品説明 (Description)

SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor ( IC50 =17.676 μM). SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma [1].

References:
[1]. Zhu J, et al. Discovery of Novel Selective Inhibitors of SMARCA2 ATPase Domain by Virtual Screening and Biological Evaluation. ACS Med Chem Lett. 2025 Sep 15;16(10):2032-2040.

製品資料 (Product Documents)

Purity:>96.00%Appearance:A solid
COASDSData Sheet

化学的性質 (Chemical Properties)

CAS番号
82131-85-9
分子式
C28H20N2O7
分子量
496.47
溶解性
DMSO: 62.5 mg/mL (125.89 mM; Need ultrasonic)
保存条件
Store at -20°C, stored under nitrogen
配送条件
評価用サンプルは保冷剤とともに発送します。その他の容量は室温で発送し、ご要望に応じて保冷剤を同梱します。

計算ツール (Calculators)モル濃度 / 希釈 / 分子量 / 単位変換 / in vivo製剤 / 溶解度

g/mol

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