Tri-GalNAc-NH2 is a synthetic tri-N-acetylgalactosamine ligand that targets the asialoglycoprotein receptor (ASGPR). Tri-GalNAc-NH2 can be used as an intermediate for constructing LYTAC antibody-ligand conjugates [1].
In Vitro, Tri-GalNAc-NH2 (compound 6) can be used as an intermediate to react and generate Tri-GalNAc-DBCO (compound 7), and antibody conjugates carrying the Tri-GalNAc ligand mediate ASGPR-dependent degradation of PCSK9 and EGFR[1].
References:
[1]. Donahue TC, et al. Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9. ACS chemical biology. 2023 Jul 21;18(7):1611-1623.
In Vitro, Tri-GalNAc-NH2 (compound 6) can be used as an intermediate to react and generate Tri-GalNAc-DBCO (compound 7), and antibody conjugates carrying the Tri-GalNAc ligand mediate ASGPR-dependent degradation of PCSK9 and EGFR[1].
References:
[1]. Donahue TC, et al. Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9. ACS chemical biology. 2023 Jul 21;18(7):1611-1623.