Adrenocorticotropic hormone (ACTH) (11-24) is a peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response, and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor (IC50 = ~1 nM in HeLa cells expressing the mouse receptor).1,2 It induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 ?M, respectively.3 Unlike ACTH (4-11), ACTH (11-24) does not induce differentiation of primary mouse melanocytes.4 In vivo, ACTH (11-24) (1.69 ?g/animal, i.c.v.) inhibits ACTH-induced stretching, yawning, and penile erections in rats.5
References:
[1]. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al.Non-corticotropic ACTH peptides modulate nerve development and regenerationRev. Neurosci.4(4)321-363(1993).
[2]. Kapas, S., Cammas, F.M., Hinson, J.P., et al.Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell lineEndocrinology137(8)3291-3294(1996).
[3]. Szalay, K.S., De Wied, D., and Stark, E.Effects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cellsJ. Steroid Biochem.32(2)259-262(1989).
[4]. Hirobe, T., and Hiroyuki, A.ACTH4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary cultureJ. Exp. Zool.286(6)632-640(2000).
[5]. Genedani, S., and Bernardi, M.ACTH-(11-24) antagonizes ACTH-(1-24)-induced behavioral syndromeNeuropeptides26(4)241-244(1994).