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APC

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APC (Anaphase-Promoting Complex) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. The APC/C's main function is to trigger the transition from metaphase to anaphase by tagging specific proteins for degradation. The two proteins of most importance that get degraded in this process as substrates of the APC/C are securin and S and M cyclins. Securin releases separase, a protease, after being degraded which in turn triggers the cleavage of cohesin, the protein complex that binds sister chromatids together. During metaphase, sister chromatids are linked by intact cohesin complexes. When securin undergoes ubiquitination by the APC/C and releases separase, which degrades cohesin, sister chromatids become free to move to opposite poles for anaphase. The APC/C also targets the mitotic cyclins for degradation, resulting in the inactivation of M-CdK (mitotic cyclin-dependent kinase) complexes, promoting exit from mitosis and cytokinesis.

Products Related to APC(6)

  • GA11219 structure
    GA11219Tos-Arg-OMe·HCl
    CAS: 1784-03-8
    Purity: >98.00%
  • GC11469 structure
    GC11469TASIN-1
    CAS: 792927-06-1
    Purity: >98%

    TASIN-1 es un inhibidor selectivo del gen APC truncado (gen de la poliposis coli adenomatosa) y ejerce efectos citotÓxicos a través de la inhibiciÓn de la biosÍntesis del colesterol. TASIN-1 representa una potencial estrategia terapéutica para la prevenciÓn e intervenciÓn en CCR con APC mutante.

  • GC17778 structure
    GC17778TAME
    CAS: 901-47-3
    Purity: >98.00%

    TAME es un inhibidor del complejo/ciclosoma promotor de la anafase (APC/C o APC), que se une a APC/C e impide su activaciÓn por Cdc20 y Cdh1, produce una detenciÓn mitÓtica. TAME no es permeable a las células.

  • GC18518 structure
    GC18518Apcin
    CAS: 300815-04-7
    Purity: >98.00%

    Apcin, un ligando de Cdc20, es un inhibidor potente y competitivo de la actividad de la ligasa E3 del complejo promotor de la anafase/ciclosoma (APC/C(Cdc20)). Apcin inhibe competitivamente la ubiquitilaciÓn dependiente de APC/C al unirse a Cdc20 y prevenir el reconocimiento del sustrato. Apcin ocupa el bolsillo de uniÓn de la caja D en la cara lateral del dominio WD40 y puede prolongar la mitosis.

  • GC62419 structure
    GC62419Apcin-A
    CAS: 1683617-62-0
    Purity: >98%

    Apcin-A, un derivado de Apcin, es un inhibidor del complejo promotor de la anafase (APC). Apcin-A interactÚa fuertemente con Cdc20 e inhibe la ubiquitinaciÓn de sustratos de Cdc20. Apcin-A se puede utilizar para sintetizar el PROTAC CP5V.

  • GC74080 structure
    GC74080TASIN-30
    CAS: 1678515-93-9
    Purity: >98.00%

    TASIN-30 es un inhibidor de EBP, con valores de EC50 de 0.097 μM para la competición de EBP y 50 μM para la competición de DHCR7, respectivamente.