Carisbamate (Synonyms: JNJ10234094, RWJ 333369) |
| Catalog No.GC18505 |
El carisbamato (RWJ-333369) es un neuromodulador activo por vÍa oral.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 194085-75-1
Sample solution is provided at 25 µL, 10mM.
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Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.
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Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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