GLPBio

Cemtirestat

Catalog No.: GC79560Purity:>98.00%Synonyms: CMTI
COASDSData Sheet
Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase ( ALR2 ).

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

Cemtirestat
Cas No.: 309283-89-4
100mgIn Stock
$49.00
1
250mgIn Stock
$84.00
1
500mgIn Stock
$128.00
1
1gIn Stock
$204.00
1
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Citas (Citations)

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase ( ALR2 ). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications [1].

References:
[1]. Hlaváč M, et al. Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket. Bioorg Med Chem. 2021;29:115885.

Documentos del producto (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
309283-89-4
Sinónimos
CMTI
Fórmula molecular
C11H8N4O2S
Peso molecular
260.27
Almacenamiento
Store at 4°C, stored under nitrogen
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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