GLPBio

Dodecylphosphocholine-d38

Catalog No.: GC47259Purity:>99.00%Synonyms: n-Dodecylphosphocholine-d38
COASDSData Sheet
La dodecilfosfocolina-d38 es la dodecilfosfocolina marcada con deuterio.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

Dodecylphosphocholine-d38
Cas No.: 130890-78-7
25 mgIn Stock
$139.00
1
50 mgIn Stock
$265.00
1
100 mgIn Stock
$471.00
1
250 mgIn Stock
$761.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

Actualmente no hay citas disponibles para este producto. A continuación se muestran publicaciones seleccionadas que citan productos GlpBio.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Descripción (Description)

Dodecylphosphocholine-d38 is the deuterium-labeled form of dodecylphosphocholine, in which 38 hydrogen atoms are replaced by deuterium (²H)[1]. Dodecylphosphocholine-d38 is intended for use as an internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS[2]. Dodecylphosphocholine-d38 is commonly used in nuclear magnetic resonance (NMR) studies of membrane protein structures[3].

References:
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2] Kurauskas, V., Hessel, A., Ma, P., et al.How detergent impacts membrane proteins: Atomic-level views of mitochondrial carriers in dodecylphosphocholineJ. Phys. Chem. Lett.9(5)933-938(2018).
[3] Hwang PM, Choy WY, Lo EI, et al. Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A. 2002;99(21):13560-13565.

Protocolo (Protocol)

PagP NMR Sample Preparation[1]
This plan is based on literature, please modify it to meet your specific needs.
1. Precipitated PagP was dissolved in 5mL of 6M Gdn-HCl, 50mM sodium phosphate (Ph=6.0). The final concentration was about 0.1mM.
2. The denatured solution was diluted dropwise into 35mL of 50mM sodium phosphate solution (pH=6.0), containing a final concentration of 0.2% Dodecylphosphocholine-d38.
3. The sample was dialyzed twice in 4L of 50mM sodium phosphate (pH=6.0) for 2h and then concentrated down to 0.45mL.
4. Finally, 50μL of D2O was added, yielding a 0.8mM PagP, 16% DPC NMR sample.

References:
[1] Hwang PM, Choy WY, Lo EI, et al. Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A. 2002;99(21):13560-13565.

Documentos del producto (Product Documents)

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
130890-78-7
Sinónimos
n-Dodecylphosphocholine-d38
Nombre químico
2-[[(dodecyl-d25-oxy)hydroxyphosphinyl]oxy]-N,N,N-tri(methyl-d3)-ethan-1,1,2,2-d4-aminium, inner salt
SMILES
O=P(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[2H])([O-])OC([2H])([2H])C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Fórmula molecular
C17D38NO4P
Peso molecular
389.7
Solubilidad
DMF: 16 mg/mL,DMSO: 16 mg/mL,Ethanol: 15 mg/mL,PBS (pH 7.2): 25 mg/ml
Almacenamiento
Store at -20°C
Consejos generales
Seleccione un disolvente adecuado según los datos de solubilidad del producto. Una vez preparada, divida la solución madre en alícuotas para evitar ciclos repetidos de congelación y descongelación.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

Reviews

Review for Dodecylphosphocholine-d38

Rating: 5
  • 5 Star100%
  • 4 Star0%
  • 3 Star0%
  • 2 Star0%
  • 1 Star0%