Glycerolipid Lipases

MAGL Inhibitor Compound 23 es un inhibidor potente, selectivo, reversible y competitivo de MAGL, con una IC50 de 80 nM. El compuesto inhibidor de MAGL 23 exhibe efectos antiproliferativos contra las células de cÁncer de mama, colorrectal y de ovario humanos. El compuesto inhibidor de MAGL 23 bloquea MAGL en ensayos basados en células e in vivo.

(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.

(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors.

KT109 es un inhibidor potente y selectivo de isoformas de la diacilglicerol lipasa-β (DAGLβ) con una IC50 de 42 nM.

LEI-106 es un potente inhibidor dual de sn-1-diacilglicerol lipasa α (DAGL-α)/ABHD6 con una IC50 de 18 nM para DAGL-α y una Ki de 0,8 μM para ABHD6.

O-7460 es un inhibidor de DAGLα potente y selectivo, con una IC50 de 0,69 μM.

KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.

An ABHD12 inhibitor

An inhibitor of MAGL

A bacterial metabolite with diverse biological activities

An internal standard for the quantification of orlistat

JNJ-42226314 es un inhibidor de la monoacilglicerol lipasa (MAGL) no covalente competitivo, altamente selectivo y reversible.