Kir4.1-IN-1 (Compound 37) is a potent, selective, blood-brain barrier permeable Kir4.1 inhibitor with an IC50 of 0.19 μM. Kir4.1-IN-1 exhibits rapid-onset antidepressant effects [1].
References:
[1]. Wang S, et al. Discovery of 2,4-Disubstituted Pyrimidine Derivatives as Novel Kir4.1 Inhibitors with Rapid-Onset Antidepressant Effect. J Med Chem. 2026 Jan 22;69(2):1606-1627.
References:
[1]. Wang S, et al. Discovery of 2,4-Disubstituted Pyrimidine Derivatives as Novel Kir4.1 Inhibitors with Rapid-Onset Antidepressant Effect. J Med Chem. 2026 Jan 22;69(2):1606-1627.