GLPBio

KLD-12 TFA

Catalog No.: GC72138Purity:>95.00%
COASDSData Sheet
KLD-12 TFA es la forma de sal TFA de KLD-12.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

KLD-12 TFA
5 mgIn Stock
$86.00
1
10 mgIn Stock
$135.00
1
25 mgIn Stock
$243.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

KLD-12 TFA is the TFA salt form of KLD-12 . KLD-12 TFA is a self a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 TFA combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 TFA hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair.

KLD-12 TFA forms self-assembled polypeptide with SDF-1, improves the survival of bone marrow stromal cells (BMSCs), promotes osteogenic differentiation of BMSCs and cell migration through Wnt/β-catenin pathway[1].

KLD-12 TFA (10-250 μg/rat, single dose, injection to infrature site) promotes bone regeneration at the fracture site in a dose-dependent manner in Sprague-Dawley rats model with drill-hole injury in femur[2].

References:
[1]. Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCsviathe Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858.
[2]. Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103.
[3]. Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001.

Documentos del producto (Product Documents)

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

Fórmula molecular
C68H122N16O19.xC2HF3O2
Peso molecular
1467.79 (free base)
Solubilidad
DMSO : 50 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Almacenamiento
Sealed storage, away from moisture
Consejos generales
Seleccione un disolvente adecuado según los datos de solubilidad del producto. Una vez preparada, divida la solución madre en alícuotas para evitar ciclos repetidos de congelación y descongelación.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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