MS117 |
| Catalog No.GC61091 |
MS117 es el primer inhibidor covalente de la proteÍna arginina metiltransferasa 6 (PRMT6) irreversible activo en las células, con una IC50 de 18 nM.
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Cas No.: 2702280-86-0
Sample solution is provided at 25 µL, 10mM.
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MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC50 of 18 nM[1].
MS117 (Compound 4) inhibits the PRMT6 methyltransferase activity in a time-dependent manner[1].MS117 (Compound 4) shows moderate selectivity (6-fold) for PRMT6 over PRMT1 (IC50 = 0.1 ± 0.025 µM) and PRMT8 (IC50 = 0.11 ± 0.01 µM) [1].
[1]. Yudao Shen, et al. Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J Med Chem. 2020 May 28;63(10):5477-5487.
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