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Beta-secretase

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Beta-secretase (BACE) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. Alzheimer's disease (AD) is caused by aggregates of the amyloid peptide (Abeta), which is generated by cleavage of the Abeta protein precursor (APP) by beta-secretase (BACE-1) followed by gamma-secretase. BACE-1 cleavage is limiting for the production of Abeta, Drugs to block this enzyme (BACE inhibitors) prevent the build up of beta-amyloid and may help slow or stop Alzheimers disease.

Products Related to Beta-secretase(27)

  • GC65970 structure
    GC65970NB-360
    CAS: 1262857-73-7
    Purity: >99.00%

    NB-360 es un inhibidor dual potente, penetrable en el cerebro y biodisponible por vÍa oral de BACE1/BACE2 (IC50: BACE1 de ratÓn y humano = 5 nM; BACE2 = 6 nM). NB-360 muestra un perfil farmacolÓgico superior y una reducciÓn sÓlida de amiloide-β y neuroinflamaciÓn en ratones transgénicos de proteÍna precursora de amiloide (APP). NB-360 puede bloquear completamente la progresiÓn de Aβ depÓsito en el cerebro de ratones transgénicos APP. NB-360 muestra una excelente selectividad sobre las aspartil proteasas pepsina, catepsina D y catepsina E relacionadas.

  • GC73144 structure
    GC73144K284-6111
    CAS: 702668-62-0
    Purity: >98.00%

    K284-6111 es un inhibidor activo de la proteína quitinasa 3-like 1 (CHI3L1).

  • GN10716 structure
    GN10716Epiberberine
    CAS: 6873-09-2
    Purity: >98.00%