Diabetes

GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption.

Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine.

Glucagon-like peptide-2 (GLP-2) is an endogenous peptide hormone formed in L cells of the small and large intestine by cleavage of proglucagon in response to nutrient ingestion.

An inactive control for glucagon receptor antagonist I

Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase.

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).

GW9578 es un agonista de PPARα selectivo de subtipo (CE50 de 5 y 50 nM para PPAR-α murino y humano) con una potente actividad reductora de lÍpidos.

Fasudil (HA-1077; AT877) dihidrocloruro es un inhibidor rhoa/roca inespecÍfico y también tiene un efecto inhibitorio en las proteÍnas quinasas, con un KI de 0.33 ⋼ m para el rock111&&&&&&77TRESTO. offlineefficient_models_2022q2.md;M, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.en_es_2021q4.mdHA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.en_es_2021q4.md

Lactisole es un antagonista canónico del receptor del sabor dulce, dirigido selectivamente a la subunidad T1R3

Lithocholic acid 3-sulfate is a metabolite of the secondary bile acid lithocholic acid.

MHY908 es un potente agonista dual de PPARα y PPARγ.

MLS-0322825 Cmpd 23 es un inhibidor selectivo de la proteÍna tirosina fosfatasa de bajo peso molecular (LMPTP), con una IC50 de 0,8 μM LMPTP-A.

Agmatine is a natural polyamine formed by the enzymatic decarboxylation of arginine.

ND-336 es un inhibidor selectivo de la metaloproteinasa de matriz (MMP)-2, MMP-9 y MMP-14, con Kis de 85, 150 y 120 nM, respectivamente.

N-Oleoyl Leucine is a fatty acid–amino acid conjugate (FAAA) that belongs to the family of N-acyl amino acids.

Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.

Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone.

Oxyntomodulin, also known as glucagon-37, is a 37-amino acid peptide produced in bovine and porcine gut.

Palmitoleic acid is an ω-7 monounsaturated fatty acid that is a common constituent of the triglycerides of human adipose tissue.

La pioglitazona (U 72107) potÁsica es un PPARγ activo por vÍa oral y selectivo; (receptor activado por proliferador de peroxisomas) agonista con uniÓn de alta afinidad al PPARγ dominio de uniÓn al ligando con EC50 de 0,93 μM y 0,99 μM para PPARγ humano y de ratÓn, respectivamente.

Platensimycin (PTM) is an antibiotic produced by S.

PTP1B Inhibitor es un inhibidor alostérico no competitivo de la proteÍna tirosina fosfatasa PTP1B, con un IC50 de 8 μM.

El etabonato de remogliflozina (GSK189075) es un inhibidor del cotransportador de sodio y glucosa (SGLT2) activo por vÍa oral, selectivo y de baja afinidad con valores de Ki de 1,95 μM, 2,14 μM, 43,1 μM, 8,57 μM para hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectivamente.

La rosiglitazona (BRL 49653) potÁsica es un PPARγ selectivo activo por vÍa oral; agonista (EC50: 60 nM, Kd: 40 nM).