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Progesterone Receptor

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Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Products Related to Progesterone Receptor(37)

  • GC50394 structure
    GC50394AG 205
    CAS: 442656-02-2
    Purity: >98.00%

    Progesterone receptor membrane component 1 (Pgrmc1) ligand

  • GC60815 structure
    GC60815Estradiol dipropionate
    CAS: 113-38-2
    Purity: >98.00%

    El dipropionato de estradiol es una combinaciÓn de estrÓgeno y progesterona, actÚa como un agonista de estrÓgeno y progesterona .

  • GC61850 structure
    GC61850Medroxyprogesterone acetate D3
    Purity: >98.00%
  • GC63143 structure
    GC63143PF-02413873
    CAS: 936345-35-6
    Purity: >99.00%

    PF-02413873 (PF-2413873) es un potente antagonista del receptor de progesterona (PR) no esteroideo, selectivo, totalmente competitivo y activo por vÍa oral, con una Ki de 2,6 nM.

  • GC63706 structure
    GC63706Dydrogesterone-D6
    Purity: >98%
  • GC63751 structure
    GC63751Levonorgestrel-D8
    Purity: >98%
  • GC63752 structure
    GC63752Norethindrone acetate-D8
    Purity: >98%
  • GC68493 structure
    GC6849317α-Hydroxyprogesterone-d8
    CAS: 850023-80-2
    Purity: >99.00%

    17α-Hydroxyprogesterone-d8 es la forma deuterada de 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hidroxiprogesterona) es una hormona progestágena endógena que actúa como intermediario químico en la biosíntesis de otras hormonas esteroides, incluyendo las hormonas glucocorticoides, andrógenos y estrógenos.

  • GC70472 structure
    GC70472Promegestone
    CAS: 34184-77-5
    Purity: >98.00%

    Promegestone (R-5020), una progestina, es un potente agonista del receptor de progesterona (PR).

  • GC70603 structure
    GC70603PF-3882845
    CAS: 1023650-66-9
    Purity: >99.00%

    PF-3882845 es un antagonista de los receptores mineralocorticoides (Unión al MR IC50=2.7 nM) para la hipertensión y la nefropatía.

  • GC71683 structure
    GC71683Chlormadinone acetate-d6-1
    Purity: >99.00%

    Chlormadinone acetate-d6-1 es acede de clormadinona marcado con deuterio.

  • GC81361 structure
    GC81361Medrogestone
    CAS: 977-79-7
    Purity: >98%

    Medrogestone is an orally active Progestin.

  • GC81362 structure
    GC81362Melengesterol
    CAS: 5633-18-1
    Purity: >98%

    Melengestrol is a steroidal progestin of the 17α-hydroxyprogesterone group and an antineoplastic agent.