GLPBio

YAP

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The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue types if its activity is increased aberrantly. YAP enhances multiple processes known to be important for tumor progression and metastasis, including cellular proliferation, transformation, migration, and invasion.

Products Related to YAP(37)

  • GC73127 structure
    GC73127GNE-7883
    CAS: 2648450-42-2
    Purity: >98.00%

    GNE-7883 es un inhibide pan-TEAD que bloquea la asociación de YAP/TAZ con TEAD.

  • GC73298 structure
    GC73298YTP-17
    Purity: >99.00%

    YTP-17 es un inhibide la interacción proteína-proteína YAP-TEAD activo por vía oral con una IC50 de 4 nM.

  • GC73349 structure
    GC73349YAP-TEAD-IN-2
    CAS: 2714432-83-2
    Purity: >98.00%

    YAP-TEAD-IN-2 (compuesto 6) es un potente inhibide la interacción proteína-proteína (PPI) con IC50 de 2,7 nM.

  • GC73457 structure
    GC73457IK-930
    CAS: 2563892-44-2
    Purity: >99.00%

    IK-930 (compuesto I-32) es un potente inhibidor de TEAD con un valor de EC50 <0.1 µM.

  • GC73562 structure
    GC73562LM-41
    CAS: 2996821-30-6
    Purity: >99.00%

    LM-41 es un inhibide la TEAD derivado del ácido flufenámico que reduce fuertemente la expresión de CTGF, Cyr61, Axl y NF2.

  • GC73564 structure
    GC73564SWTX-143
    CAS: 2766575-48-6
    Purity: >99.00%

    SWTX-143 es un inhibiyap /TAZ-TEAD activo por vía oral que se une a la bolsa de palmitoilación de las cuatro isoformas TEAD.

  • GC73569 structure
    GC73569MY-1076
    CAS: 3008262-76-5
    Purity: >99.00%

    MY-1076 es un inhibidor de YAP.

  • GC73954 structure
    GC73954BAY-593
    CAS: 2413020-56-9
    Purity: >99.00%

    BAY-593 es un inhibidor activo de la GGTase-I.

  • GC73955 structure
    GC73955(7S)-BAY-593
    CAS: 2413068-25-2
    Purity: >99.00%

    (7S)-BAY-593 es el s-enantiómero de BAY-593.

  • GC74115 structure
    GC74115YAP/TAZ inhibitor-3
    CAS: 2506273-81-8
    Purity: >99.00%

    YAP/TAZ inhibitor-3 (compuesto 24) es un inhibidor de YAP/TAZ.

  • GC81347 structure
    GC81347YAP/TEAD-IN-2
    CAS: 2957895-40-6
    Purity: >95.00%

    YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor.

  • GC81349 structure
    GC81349(R,S)-YAP-TEAD-IN-2
    Purity: >98.00%

    (R,S)-YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2.

  • GC81778 structure
    GC81778LATS-IN-2
    CAS: 2248728-49-4
    Purity: >99.00%

    LATS-IN-2 is an efficiently acting LATS ( large tumor suppressor kinase) inhibitor.