GLPBio

RVG Peptide (trifluoroacetate salt)

Catalog No.: GC92117Purity:>98.00%Synonyms: Rabies Virus Glycoprotein; Rabies Virus Glycoprotein 29; RABV-G; RVG29
COASDSData Sheet
RVG Peptide (trifluoroacetate salt) es un antagonista del receptor nicotínico acetilcolina (nAChR) (IC50 = 2,5 μM para el receptor humano).

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RVG Peptide (trifluoroacetate salt)
1 mgIn Stock
$69.00
1
5 mgIn Stock
$241.00
1
10 mgIn Stock
$378.00
1
25 mgIn Stock
$771.00
1
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Citas (Citations)

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  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Descripción (Description)

Rabies virus glycoprotein (RVG) peptide is a nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 2.5 ?M for the human receptor).1 Lipid nanoparticles (LNPs) conjugated to RVG peptide selectively traffic to the brain over the lungs and liver in rats.2 LNPs conjugated to RVG peptide and encapsulating the iron chelator and prolyl hydroxylase inhibitor deferoxamine (DFO) reduce iron levels in the striatum and substantia nigra, as well as decrease levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and increase levels of superoxide dismutase (SOD) in the substantia nigra in a mouse model of MPTP-induced Parkinson's disease. RVG-containing and DFO-encapsulating LNPs also increase the latency to fall in the rotarod test in the same model.

References:
[1]. Lentz, T.L., Hawrot, E., and Wilson, P.T.Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptorProteins2(4)298-307(1987).
[2]. You, L., Wang, J., Liu, T., et al.Correction to targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in Parkinsonian miceACS Nano16(11)19605(2022).

Documentos del producto (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

Sinónimos
Rabies Virus Glycoprotein; Rabies Virus Glycoprotein 29; RABV-G; RVG29
Nombre químico
L-tyrosyl-L-threonyl-L-isoleucyl-L-tryptophyl-L-methionyl-L-prolyl-L-α-glutamyl-L-asparaginyl-L-prolyl-L-arginyl-L-prolylglycyl-L-threonyl-L-prolyl-L-cysteinyl-L-α-aspartyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-arginylglycyl-L-lysyl-L-arginyl-L-alanyl-L-seryl-L-asparaginyl-glycine, trifluoroacetate salt
SMILES
O=C(N[C@]([C@H](O[H])C)([H])C(N[C@@](C(N[C@@H](CC1=CN([H])C2=C1C=CC=C2)C(N[C@@H](CCSC)C(N3CCC[C@H]3C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N[H])=O)C(N4CCC[C@H]4C(N[C@@H](CCC/N=C(N[H])/N)C(N5CCC[C@H]5C(NCC(N[C@]([C@H](O[H])C)([H])C(N6CCC[C@H]6C(N[C@@H](CS[H])C(N[C@@H](CC(O)=O)C(N[C@@](C(N[C@H](C(N[C@]([C@H](O[H])C)([H])C(N[C@@H](CC(N[H])=O)C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@@H](CC(N[H])=O)C(NCC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC8=CC=C(O[H])C=C8)N[H].FC(F)(C(O)=O)F
Fórmula molecular
C141H217N43O43S2 ? XCF3COOH
Peso molecular
3266.6
Solubilidad
DMSO: Soluble: ≥10 mg/ml,PBS (pH 7.2): Soluble: ≥10 mg/ml
Almacenamiento
-20°C
Consejos generales
Seleccione un disolvente adecuado según los datos de solubilidad del producto. Una vez preparada, divida la solución madre en alícuotas para evitar ciclos repetidos de congelación y descongelación.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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