(S)-Pro-xylane (Synonyms: (S)-Hydroxypropyl tetrahydropyrantriol) |
Catalog No.GC60007
One-Click Copy Product Info
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(S)-pro-xilano ((S)-hidroxipropiltetrahidropirantriol) es el enantiÓmero S de pro-xilano.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 868156-46-1
Sample solution is provided at 25 µL, 10mM.
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(S)-Pro-xylane, a biologically active C-glycoside compound, is an important ingredient in antiaging skincare formulations in cosmetic products [1]. Through mimicking natural β-O-xylosides in skin, (S)-Pro-xylane is effective in stimulating the biosynthesis of glycosaminoglycans (GAGs), which leads to the preservation of matrix integrity and thereby contributes to skin's mechanical properties, such as elasticity and hydration [2]. (S)-Pro-xylane has been widely used to prevent the degradation and loss of glycosaminoglycans and proteoglycans in vivo[3].
In vitro, (S)-Pro-xylane treatment at 0.4mg/ml for 18h significantly enhanced the mRNA levels of collagen VII a1 and collagen IV a1 in normal human epidermal keratinocytes (NHKs), without affecting cell viability[4]. Treatment with 3mM (S)-Pro-xylane for 3 days increased syndecan 4 and perlecan levels in an ex vivo atrophic skin model[5].
In vivo, topical application of 100μl 1.5mg/ml (S)-Pro-xylane aqueous solution daily for 3 weeks significantly improved collagen loss and fiber breakage associated with skin aging, and reduced the degradation of elastic fibers associated with skin aging in Sprague-Dawley (SD) rats[6].
References:
[1] Zhao Y, Li Y, Shang J, et al. Engineering a Carbonyl Reductase for High-Efficiency Synthesis of Optically Pure (S)-Pro-Xylane: An Alternative Synthetic Route[J]. Journal of Agricultural and Food Chemistry, 2025, 73(16): 9759-9768.
[2] Dou Z, Hu P R, Song L L, et al. Extensive gene mining and facile engineering of a novel carbonyl reductase for asymmetric synthesis of anti-aging (S)-Pro-Xylane from d-xylose[J]. International Journal of Biological Macromolecules, 2025, 305: 140976.
[3] Lu J, Jiang Z, Xie X, et al. Efficient biosynthesis of Pro-Xylane through semi-rational engineering of carbonyl reductase from Canariomyces notabilis[J]. Molecular Catalysis, 2025, 579: 115020.
[4] Sok J, Pineau N, Dalko-Csiba M, et al. Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative[J]. European Journal of Dermatology, 2008, 18(3): 297-302.
[5] Pineau N, Bernerd F, Cavezza A, et al. A new C-xylopyranoside derivative induces skin expression of glycosaminoglycans and heparan sulphate proteoglycans[J]. European Journal of Dermatology, 2008, 18(1): 36-40.
[6] Yang A, Ma C, Song Q, et al. Anti-Aging Efficacy of Fructosazine and Deoxyfructosazine: A Comprehensive In Vitro and In Vivo Analysis[J]. Molecules, 2025, 30(11): 2263.
| Cell experiment [1]: | |
Cell lines | Normal human dermal fibroblasts (NHDFs) |
Preparation Method | Normal human dermal fibroblasts (NHDFs) were cultured in DMEM medium supplemented with 10% fetal bovine serum, 1% penicillin-streptomycin and amphotericin B triple antibiotic solution. Cells were cultured in a 5% CO2 incubator at 37°C. Cells were treated with 0.4mg/ml of (S)-Pro-xylane for 18h and analyzed for cell viability and mRNA levels of collagen VII a1 and collagen IV a1. |
Reaction Conditions | 0.4mg/ml; 18h |
Applications | (S)-Pro-xylane treatment significantly enhanced the mRNA levels of collagen VII a1 and collagen IV a1, without affecting cell viability. |
| Animal experiment [2]: | |
Animal models | Male Sprague-Dawley rats |
Preparation Method | Male Sprague-Dawley rats were housed under controlled conditions (22±3°C, 12/12h light/dark cycle) and randomly assigned to experimental groups. Two skin areas, each measuring 2cm×2cm, were selected from the back of each rat, and the hair at the sampling sites was shaved. For each rat, one skin area was designated as the negative control, while the other was used as the (S)-Pro-xylane-treated group. The skin in the (S)-Pro-xylane-treated group was topically applied with 100μl 1.5mg/ml (S)-Pro-xylane aqueous solution (containing 10% propylene glycol) daily for 3 weeks. Rat skin morphology, collagen fibers, and elastic fibers were analyzed. |
Dosage form | 1.5mg/ml (100μl); Once a day for 3 weeks; topical application |
Applications | (S)-Pro-xylane treatment can improve the skin condition of rats, resulting in an increase in the content of collagen fibers and elastic fibers in the skin. |
References: | |
| Cas No. | 868156-46-1 | SDF | |
| Sinónimos | (S)-Hydroxypropyl tetrahydropyrantriol | ||
| Canonical SMILES | C[C@H](O)C[C@H](OC[C@H]1O)[C@@H]([C@H]1O)O | ||
| Formula | C8H16O5 | M.Wt | 192.21 |
| Solubility | DMSO: 250 mg/mL (1300.66 mM) | Storage | 4°C, away from moisture and light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2026 mL | 26.0132 mL | 52.0264 mL |
| 5 mM | 1.0405 mL | 5.2026 mL | 10.4053 mL |
| 10 mM | 520.3 μL | 2.6013 mL | 5.2026 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)