SIBA |
| Catalog No.GC33442 |
SIBA (5'-isobutiltioadenosina) es un inhibidor de la transmetilaciÓn (anÁlogo de SAH), con una potente actividad antiproliferativa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 35899-54-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
SIBA selectively inhibits spermine synthase, IC50=8 uM.IC50 value: 8 uMTarget: spermine synthaseSIBA is a powerful antiproliferative drug. SIBA has been reported to inhibit cell transformation induced by oncogenic RNA or DNA viruses, the growth of transformed mouse mammary cells, the mitogen-stimulated blastogenesis of lymphocytes and the capping of herpes virus mRNA 161. It has also been demonstrated that an antimalarial activity is exerted by SIBA against Plasmodium falciparum in cultures.
[1]. Carteni-Farina M, et al. Studies on the metabolism of 5'-isobutylthioadenosine (SIBA): phosphorolytic cleavage by methylthioadenosinephosphorylase. FEBS Lett. 1979 Aug 15;104(2):266-270. [2]. Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryofibroblasts. Biochem J. 1982 Jun 15;204(3):853-859.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *