1-Methyl-4-nitrosopiperazine -d 11 (MNP-d 11 ) is the deuterium labeled 1-Methyl-4-nitrosopiperazine. 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics [1].
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Larimer FW, et al. Mutagenicity of N-nitrosopiperazine derivatives in Saccharomyces cerevisiae. Mutat Res. 1980 Feb;77(2):143-8.
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Larimer FW, et al. Mutagenicity of N-nitrosopiperazine derivatives in Saccharomyces cerevisiae. Mutat Res. 1980 Feb;77(2):143-8.