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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC63267 α-​Chaconine α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-​Chaconine Chemical Structure
  3. GC66197 α-?Terpinyl acetate α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM. α-?Terpinyl acetate Chemical Structure
  4. GC65446 α-Amyrin acetate α-Amyrin acetate, a natural triterpenoid, has anti-inflammatory activity, antispasmodic profile and the relaxant effect. α-Amyrin acetate Chemical Structure
  5. GC63268 α-Amyrin palmitate α-Amyrin palmitate is isolated from Santalum album (sandalwood). α-Amyrin palmitate Chemical Structure
  6. GC26093 α-Conotoxin GI α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ. α-Conotoxin GI Chemical Structure
  7. GC63269 α-Conotoxin PIA TFA α-Conotoxin PIA TFA Chemical Structure
  8. GC52338 α-Conotoxin PnIA (trifluoroacetate salt)

    α-CtxPnIA, αPnIA

     A peptide antagonist of α3β2-subunit containing and α7 nAChRs α-Conotoxin PnIA (trifluoroacetate salt) Chemical Structure
  9. GC63723 α-Conotoxin PnIA TFA α-Conotoxin PnIA TFA Chemical Structure
  10. GC49838 α-Cortolone

    20α-Cortolone, NSC 59872

     A metabolite of cortisol α-Cortolone Chemical Structure
  11. GC52253 α-Enolase (1-19)-biotin Peptide

    Enolase-1 (1-19)-biotin

     A biotinylated α-enolase peptide α-Enolase (1-19)-biotin Peptide Chemical Structure
  12. GC70181 α-Glucosidase-IN-22

    Alpha-glucosidase-IN-22 (compound 7i) is a benzimidazole, an effective inhibitor of alpha-glucosidase with an IC50 of 0.64 μM. Alpha-glucosidase-IN-22 is an effective anti-diabetic active molecule with potential for use in type 2 diabetes (T2DM) research.

     α-Glucosidase-IN-22 Chemical Structure
  13. GC72710 α-Glucosidase-IN-35 α-Glucosidase-IN-35 (compound 1) is a kind of chromene. α-Glucosidase-IN-35 Chemical Structure
  14. GC66088 α-Helical CRF(9-41) TFA α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM. α-Helical CRF(9-41) TFA Chemical Structure
  15. GC67685 α-Isopropylmalate

    α-IPM

     α-Isopropylmalate Chemical Structure
  16. GC63749 α-Lipoic Acid-d5

    Thioctic acid-d5; (±)-α-Lipoic acid-d5; DL-α-Lipoic acid-d5

     α-Lipoic Acid-d5 Chemical Structure
  17. GC67540 α-Lipoic acid-NHS

    DL-α-Lipoic acid-NHS

     α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. α-Lipoic acid-NHS Chemical Structure
  18. GC65892 α-Methyl-p-tyrosine α-Methyl-p-tyrosine is a competitive inhibitor of the enzyme tyrosine hydroxylase, which converts tyrosine to Levodopa (DOPA). α-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to DOPA. α-Methyl-p-tyrosine Chemical Structure
  19. GC64563 α-Methylserotonin α-Methylserotonin Chemical Structure
  20. GC63941 α-Solanine α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in potatoes, has been observed to inhibit growth and induce apoptosis in cancer cells. α-Solanine Chemical Structure
  21. GC63615 α-Thujone α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone Chemical Structure
  22. GC67618 α-Tocopherol phosphate disodium

    alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium

     α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis. α-Tocopherol phosphate disodium Chemical Structure
  23. GC68390 α5β1 integrin agonist-1 α5β1 integrin agonist-1 Chemical Structure
  24. GC70953 α7 nAchR-JAK2-STAT3 agonist 1 α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 Chemical Structure
  25. GC70179 α7 Nicotinic receptor agonist-1

    Alpha-7 Nicotinic receptor agonist-1 (Preparation 5) is an alpha-7 nAChR agonist. It can be used for research on psychiatric disorders such as schizophrenia, mania or bipolar disorder, and anxiety disorders, as well as intellectual disabilities such as Alzheimer's disease, learning deficits, cognitive impairments, attention deficits, memory loss, Lewy body dementia and attention deficit hyperactivity disorder.

     α7 Nicotinic receptor agonist-1 Chemical Structure
  26. GC64932 αvβ5 integrin-IN-1 αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (pIC50 = 8.2) . αvβ5 integrin-IN-1 Chemical Structure
  27. GC49467 β-Aescin A triterpenoid saponin with diverse biological activities β-Aescin Chemical Structure
  28. GC70787 β-Aminoarteether β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether Chemical Structure
  29. GC63273 β-Amyloid (1-14),mouse,rat β-Amyloid (1-14),mouse,rat Chemical Structure
  30. GC66089 β-Amyloid (1-40) (TFA)

    Amyloid Beta-Peptide (1-40) (human) TFA; Amyloid β-Peptide (1-40) (human) TFA

     β-Amyloid (1-40) TFA is a primary protein in plaques found in the brains of patients with Alzheimer's disease. β-Amyloid (1-40) (TFA) Chemical Structure
  31. GC70182 β-Amyloid (1-40), FAM-labeled TFA

    Beta-amyloid (1-40), FAM-labeled TFA is a FAM fluorescently labeled beta-amyloid (1-40) peptide (Λex= 492 nm and Λem= 518 nm).

     β-Amyloid (1-40), FAM-labeled TFA Chemical Structure
  32. GC63274 β-Amyloid (1-42), (rat/mouse) (TFA)

    Amyloid β-peptide (1-42) (rat/mouse) TFA

     β-Amyloid (1-42), (rat/mouse) (TFA) Chemical Structure
  33. GC66416 β-Amyloid (22-35) (TFA)

    Amyloid β-Protein (22-35) (TFA)

     β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution). β-Amyloid (22-35) (TFA) Chemical Structure
  34. GC66346 β-Amyloid (42-1), human TFA

    Amyloid β Peptide (42-1)(human) TFA

     β-Amyloid (42-1), human TFA is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. β-Amyloid (42-1), human TFA Chemical Structure
  35. GC71998 β-Amyrin acetate β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-perlipidemic activities. β-Amyrin acetate Chemical Structure
  36. GC66340 β-Amyrone

    β-Amyron

     β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity. β-Amyrone Chemical Structure
  37. GC71980 β-Caryophyllene-d2 β-Caryopllene-d2 is deuterium labeled β-Caryopllene. β-Caryophyllene-d2 Chemical Structure
  38. GC63275 β-Cryptoxanthin β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from Satsuma mandarin orange, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin Chemical Structure
  39. GC63276 β-Cyclocitral β-Cyclocitral, a volatile oxidized derivative of β-carotene, is a grazer defence signal unique to the Cyanobacterium Microcystis. β-Cyclocitral Chemical Structure
  40. GC63277 β-Cyclogeraniol β-Cyclogeraniol is a natural odour compound. β-Cyclogeraniol Chemical Structure
  41. GC66870 β-D-Glucan β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery. β-d-glucan is an enteric delivery vehicle for probiotics. β-D-Glucan Chemical Structure
  42. GC63278 β-D-Glucose pentaacetate β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction. β-D-Glucose pentaacetate Chemical Structure
  43. GC66750 β-D-glucuronide-pNP-carbonate β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). β-D-glucuronide-pNP-carbonate Chemical Structure
  44. GC52494 β-Endorphin (rat) (trifluoroacetate salt) An opioid neuropeptide β-Endorphin (rat) (trifluoroacetate salt) Chemical Structure
  45. GC66512 β-Estradiol-6-one 6-(O-carboxymethyloxime) β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. β-Estradiol-6-one 6-(O-carboxymethyloxime) Chemical Structure
  46. GC49769 β-Glucogallin

    1-O-Galloyl-β-D-glucose

     A plant metabolite and an aldose reductase 2 inhibitor β-Glucogallin Chemical Structure
  47. GC64430 β-Glucuronidase-IN-1 β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. β-Glucuronidase-IN-1 Chemical Structure
  48. GC49890 β-Glycerophosphate-d5 (sodium salt hydrate)

    Glycerol 2-Phosphate-d5

     An internal standard for the quantification of β-glycerophosphate β-Glycerophosphate-d5 (sodium salt hydrate) Chemical Structure
  49. GC49647 β-Hyodeoxycholic Acid (hydrate)

    3β,6α-dihydroxy-5β-Cholan-24-oic Acid, isoHDCA, Isohyodeoxycholic Acid

     A 3β epimer of hyodeoxycholic acid β-Hyodeoxycholic Acid (hydrate) Chemical Structure
  50. GC64619 β-Ionone β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity. β-Ionone Chemical Structure
  51. GC66842 β-Methylcrotonyl coenzyme A lithium β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase). β-Methylcrotonyl coenzyme A lithium Chemical Structure
  52. GC70184 β-Naphthoflavone-CH2-Br

    β-NF-CH2-Br

    Beta-naphthoflavone-CH2-Br is an aryl hydrocarbon receptor (AhR) ligand. It is used in the synthesis of PROTAC Beta-NF-JQ1.

     β-Naphthoflavone-CH2-Br Chemical Structure
  53. GC67484 β-Nicotinamide adenine dinucleotide reduced dipotassium β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle. β-Nicotinamide adenine dinucleotide reduced dipotassium Chemical Structure
  54. GC70185 β-Sitostenone

    δ4-Sitosterol-3-one; β-Rosasterol oxide

    Beta-sitostenone is a sterol isolated from Cochlospermum vitifolium. It can inhibit the activity of tyrosinase and has anti-melanogenesis and anti-tumor activities.

     β-Sitostenone Chemical Structure
  55. GC70650 γ-Acetylenic GABA hydrochloride γ-Acetylenic GABA (GAG) drochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride Chemical Structure
  56. GC64508 γ-Aminobutyric acid-d6

    γ-Aminobutyric acid-d6 (4-Aminobutyric acid-d6) is the deuterium labeled γ-Aminobutyric acid.

     γ-Aminobutyric acid-d6 Chemical Structure
  57. GC49865 γ-D-Glutamylglycine (trifluoroacetate salt)

    γ-DGG

     An excitatory amino acid antagonist γ-D-Glutamylglycine (trifluoroacetate salt) Chemical Structure
  58. GC52400 γ-Glu-Ala (trifluoroacetate salt)

    γ-Glutamylalanine, γ-L-Glutamyl-L-alanine

     A dipeptide γ-Glu-Ala (trifluoroacetate salt) Chemical Structure
  59. GC63279 γ-Glu-Gly TFA γ-Glu-Gly TFA Chemical Structure
  60. GC52404 γ-Glu-Phe (trifluoroacetate salt)

    γ-Glutamylphenylalanine

     A dipeptide with metabolism-altering activity γ-Glu-Phe (trifluoroacetate salt) Chemical Structure
  61. GC70186 γ-Glutamylornithine

    Gamma-glutamylornithine is a urine excretion product of patients with HHH syndrome (hyperuricemia, hyperammonemia, and homocitrullinuria) and patients with uric acid-related recurrent ataxia. Increased endogenous ornithine levels lead to an increase in gamma-glutamylornithine levels in the urine.

     γ-Glutamylornithine Chemical Structure
  62. GC63280 γ-Hexalactone γ-Hexalactone is a gamma-lactone found in ripe fruits. γ-Hexalactone Chemical Structure
  63. GC66048 δ-Secretase inhibitor 11 δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research. δ-Secretase inhibitor 11 Chemical Structure
  64. GC70188 ω-Agatoxin IVA TFA

    ω-Agatoxin IVA TFA is an effective selective blocker of P/Q-type Ca2+ (Cav2.1) channels, with IC50 values of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA TFA (IC50, 30-225 nM) inhibits high potassium-induced glutamate release and calcium influx. It also blocks the release of serotonin and adrenaline induced by high potassium, without affecting L-type or N-type calcium channels.

     ω-Agatoxin IVA TFA Chemical Structure
  65. GC64899 ω-Conotoxin MVIIC TFA ω-Conotoxin MVIIC TFA Chemical Structure
  66. GC63281 ω-Pentadecalactone ω-Pentadecalactone is a fragrance ingredient. ω-Pentadecalactone Chemical Structure
  67. GC70556 ß-pBrPh-Glc β-pBrPh-Glc is a small-molecule ice recrystallization inhibitor. ß-pBrPh-Glc Chemical Structure
  68. GC67191 (±)-α-Tocopherol nicotinate (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases. (±)-α-Tocopherol nicotinate Chemical Structure
  69. GC52010 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid

    αHYA, (±)-10-hydroxy-12(Z),15(Z)-ODE

     An oxylipin gut microbiota metabolite (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid Chemical Structure
  70. GC52013 (±)-10-hydroxy-12(Z)-Octadecenoic Acid

    10-hydroxy-cis-12-Octadecenoic Acid

     An oxylipin and metabolite of linoleic acid (±)-10-hydroxy-12(Z)-Octadecenoic Acid Chemical Structure
  71. GC52421 (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5

    10-hydroxy-cis-12-Octadecenoic Acid-d5

     An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5 Chemical Structure
  72. GC52260 (±)-Cenobamate An Analytical Reference Standard (±)-Cenobamate Chemical Structure
  73. GC72625 (±)-Coniine hydrochloride (±)-Coniine drochloride (2-Propylpiperidine drochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride Chemical Structure
  74. GC49515 (±)-Ibuprofen-d3 (sodium salt)

    DL-Ibuprofen-d3

     An internal standard for the quantification of (±)-ibuprofen (±)-Ibuprofen-d3 (sodium salt) Chemical Structure
  75. GC65599 (±)-Leucine-d10 (±)-Leucine-d10 Chemical Structure
  76. GC52224 (±)-MMT5-14 A derivative of remdesivir with antiviral activity (±)-MMT5-14 Chemical Structure
  77. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride)

    Wy 45494

     A minor active metabolite of venlafaxine (±)-N-desmethyl Venlafaxine (hydrochloride) Chemical Structure
  78. GC49482 (±)-Nornicotine-d4

    DL-Nornicotine-d4, (R,S)-Nornicotine-d4

     An internal standard for the quantification of (±)-nornicotine (±)-Nornicotine-d4 Chemical Structure
  79. GC67928 (±)-Stylopine hydrochloride

    Tetrahydrocoptisine hydrochloride

     (±)-Stylopine hydrochloride Chemical Structure
  80. GC64007 (±)-U-50488 hydrate hydrochloride

    (±)-Trans-(1R,2R)-U-50488 hydrate hydrochloride

     (±)-U-50488 hydrate hydrochloride Chemical Structure
  81. GC67681 (αR,8aS)-GSK1614343 (αR,8aS)-GSK1614343 Chemical Structure
  82. GN10155 (+)- Corydaline

    (+)-Corydaline, D-Corydaline, NSC 406036

     (+)- Corydaline Chemical Structure
  83. GN10612 (+)- Praeruptorin C (+)- Praeruptorin C Chemical Structure
  84. GN10745 (+)-Bicuculline

    NSC 32192

     (+)-Bicucline ((+)-Bicucline )) is a competitive GABAA receptor antagonist with an IC50 of 2μM. (+)-Bicuculline Chemical Structure
  85. GC64752 (+)-Biotin-ONP

    (+)-Biotin 4-nitrophenyl ester

     (+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. (+)-Biotin-ONP Chemical Structure
  86. GC66864 (+)-Biotin-PEG2-hydrazide (+)-Biotin-PEG2-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. (+)-Biotin-PEG2-hydrazide Chemical Structure
  87. GC66692 (+)-Biotin-SLC (+)-Biotin-SLC is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. (+)-Biotin-SLC Chemical Structure
  88. GN10605 (+)-Catechin hydrate

    D-(+)-Catechin, Catechuic Acid, Cyanidol

     (+)-Catechin hydrate Chemical Structure
  89. GC63999 (+)-Coclaurine hydrochloride

    (+)-(R)-Coclaurine hydrochloride; (R)-Coclaurine hydrochloride; d-Coclaurine hydrochloride

     (+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride Chemical Structure
  90. GN10654 (+)-Corynoline

    (+)-Corynoline, 13-methyl-Chelidonine, CRL, (d)-Corynoline

     (+)-Corynoline Chemical Structure
  91. GC70265 (+)-EMD 57033 (+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+)-EMD 57033 Chemical Structure
  92. GC64207 (+)-JNJ-A07 (+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 Chemical Structure
  93. GC67931 (+)-Medioresinol (+)-Medioresinol Chemical Structure
  94. GC16616 (+)-MK 801

    Dizocilpine maleate;Dizocilpine hydrogen maleate;(+)-MK 801;MK 801

     (+)-MK 801 Chemical Structure
  95. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine Chemical Structure
  96. GC63969 (+)-Schisandrin B (+)-Schisandrin B is an enantiomer of Schisandrin B. (+)-Schisandrin B Chemical Structure
  97. GC69720 (+)SHIN2

    (+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, and its in vivo target can be traced using 13C-serine. (+)SHIN2 increases the survival rate of mice with primary acute T-cell lymphoblastic leukemia (T-ALL) driven by Notch1 and has a synergistic effect with Methotrexate.

     (+)SHIN2 Chemical Structure
  98. GC49502 (-)-β-Sesquiphellandrene A sesquiterpene with antiviral and anticancer activities (-)-β-Sesquiphellandrene Chemical Structure
  99. GC63940 (-)-Denudatin B (-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B Chemical Structure
  100. GC14049 (-)-Epigallocatechin gallate (EGCG)

    EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  101. GC69463 (-)-GSK598809 hydrochloride

    (1S,5R)-GSK598809 hydrochloride

    (-)-GSK598809 is an isomer of GSK598809. GSK598809 is a selective antagonist of the dopamine D3 receptor (DRD3).

     (-)-GSK598809 hydrochloride Chemical Structure

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