GLPBio

15(S)-15-methyl Prostaglandin F2α ethyl amide

Catalog No.: GC52511Purity:>95.00%Synonyms: 15(S)15methyl PGF2α ethyl amide
COASDSData Sheet
Analog of 15(S)-15-methyl PGF2α methyl ester

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15(S)-15-methyl Prostaglandin F2α ethyl amide
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Citations

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    31, 1291–1307 (2021)

Description

15(S)-15-methyl Prostaglandin F2α has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor.1,2 15(S)-15-methyl PGF2α ethyl amide is a lipophilic analog of 15(S)-15-methyl PGF2α methyl ester. Prostaglandin esters are generally hydrolyzed to the free acid upon in vivo administration, making the methyl esters useful prodrugs.3 Hydrolysis of prostaglandin amides in vivo is not thoroughly established.

1.Carlan, S.J., Gushwa, J.P., O'Brien, W.F., et al.Effect of intramuscular 15-methyl prostaglandin F2α after second-trimester deliveryObstet. Gynecol.895-9(1997) 2.Lindblom, B., KÄllfelt, B., Hahlin, M., et al.Local prostaglandin F2α injection for termination of ectopic pregnancyLancet776-777(1987) 3.Miller, W.L., and Sutton, M.J.Relative biological activity of certain prostaglandins and their enantiomersProstaglandins11(1)77-84(1976)

Product Documents

Purity:>95.00%Appearance:A solution in ethanol
COASDSData Sheet

Chemical Properties

Synonyms
15(S)15methyl PGF2α ethyl amide
SMILES
O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(NCC)=O)[C@H]1/C=C/[C@](O)(C)CCCCC
Molecular Formula
C23H41NO4
Molecular Weight
395.6
Solubility
DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 0.5 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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