GLPBio

2,2'-O-Anhydro-5-methyluridine

Catalog No.: GF39659Purity:>99.00%
COASDSData Sheet
TK-112690 is aUPP1inhibitor.

Products are for research use only. Not for human use. We do not sell to patients.

2,2'-O-Anhydro-5-methyluridine
Cas No.: 22423-26-3
10mm (in 1mL DMSO)In Stock
$14.00
1
10gIn Stock
$12.00
1
25gIn Stock
$22.00
1
50gIn Stock
$35.00
1
100gIn Stock
$55.00
1
500gIn Stock
$132.00
1
1kgIn Stock
$210.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

TK-112690 is aUPP1inhibitor. TK-112690 inhibits murine small intestinal uridinephosphorylase(UPase) with anIC50of 12.5 μM and human small intestinal UPase with anIC50of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study ofcancerand pulmonary fibrosis[1][2][3].

References:
[1].Strefeler A, et al. Nucleosides are overlooked fuels in central carbon metabolism. Trends Endocrinol Metab. 2024 Apr;35(4):290-299.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
22423-26-3
Molecular Formula
C10H12N2O5
Molecular Weight
240.21
Solubility
DMSO : 50 mg/mL(208.15 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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