8-(p-Sulfophenyl)theophylline (8-SPT) (compound 2) is an adenosine A2B receptor antagonist, with a K i of 1330 nM for A2B human recombinant [1].
References:
[1]. Yan L, et al. A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists. J Med Chem. 2006 Jul 13;49(14):4384-91.
References:
[1]. Yan L, et al. A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists. J Med Chem. 2006 Jul 13;49(14):4384-91.