AA26-9 (Synonyms: AA26-9, KK007-N1) |
| Catalog No.GC31355 |
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1312782-34-5
Sample solution is provided at 25 µL, 10mM.
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AA26-9 is a potent and broad spectrum serine hydrolase inhibitor.
AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme's serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells[1].
[1]. Adibekian A, et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011 May 15;7(7):469-78.
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