ABC transporter modulator-2 (Compound I-200) is a ABC transporter expression modulator. ABC transporter modulator-2 upregulates the expression of wild-type ABCC6 with an EC 50 of <1 μM. ABC transporter modulator-2 upregulates the expression of wild-type ABCB4 with an EC 50 of <1 μM. ABC transporter modulator-2 upregulates the expression of wild-type ABCD2 with an EC 50 of <1 μM. ABC transporter modulator-2 upregulates the expression of the ABCA4 P1380L mutant with an EC 50 of <1 μM. ABC transporter modulator-2 can be used in the research of diseases associated with ABC transporter dysfunction [1].
In Vitro, ABC transporter modulator-2 upregulates the expression of ABCC6 WT with an EC50 of <1 μM[1]. ABC transporter modulator-2 upregulates the expression of ABCB4 WT with an EC50 of <1 μM[1]. ABC transporter modulator-2 increases the expression level of the ABCA4P1380L mutant, with an EC50 of <1 μM[1]. ABC transporter modulator-2 upregulates the expression of ABCD2 WT with an EC50 of <1 μM[1].
References:
[1]. Nathan Oliver Fuller, et al. Pyridinyloxypyridines as modulators of atp -binding cassette transporters and their use in treating medical conditions. WO2025151724A1. WIPO (PCT). 2025-01-10.
In Vitro, ABC transporter modulator-2 upregulates the expression of ABCC6 WT with an EC50 of <1 μM[1]. ABC transporter modulator-2 upregulates the expression of ABCB4 WT with an EC50 of <1 μM[1]. ABC transporter modulator-2 increases the expression level of the ABCA4P1380L mutant, with an EC50 of <1 μM[1]. ABC transporter modulator-2 upregulates the expression of ABCD2 WT with an EC50 of <1 μM[1].
References:
[1]. Nathan Oliver Fuller, et al. Pyridinyloxypyridines as modulators of atp -binding cassette transporters and their use in treating medical conditions. WO2025151724A1. WIPO (PCT). 2025-01-10.