AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model. Pharmacologic inhibition of aggrecanase activity in humans using AGG-523 may be an effective treatment for slowing cartilage degradation following joint injury.
AGG-523
Catalog No.: GB62287Purity:>98%Synonyms: AGG-523; AGG 523; AGG523; PF-05212371; PF 05212371; PF05212371; WAY-266523; WAY 266523; WAY266523;
AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 920289-29-8
1mgQuote
$90.00
5mgQuote
$350.00
10mgQuote
$550.00
25mgQuote
$950.00
50mgQuote
$1,650.00
100mgQuote
$2,950.00
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 1mg | $90.00 | Quote | -- | |
| 5mg | $350.00 | Quote | -- | |
| 10mg | $550.00 | Quote | -- | |
| 25mg | $950.00 | Quote | -- | |
| 50mg | $1,650.00 | Quote | -- | |
| 100mg | $2,950.00 | Quote | -- |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Chemical Properties
CAS No.
920289-29-8
Synonyms
AGG-523; AGG 523; AGG523; PF-05212371; PF 05212371; PF05212371; WAY-266523; WAY 266523; WAY266523;
SMILES
CC(C)(Cc1ccc(F)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)c2ccc(cc2)c3ccccc3
Molecular Formula
C28H29FN2O4
Molecular Weight
476.5484
Solubility
Soluble in DMSO
Storage
Store at-20℃
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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