Anti-Mouse LAG-3 Antibody (C9B7W) is an anti-mouse LAG-3 IgG1 monoclonal antibody. Anti-Mouse LAG-3 Antibody (C9B7W) can enhance CD4 + T cell function and exert anti-tumor effects without blocking the interaction between LAG-3 and MHCII. Anti-Mouse LAG-3 Antibody (C9B7W) can be used for research on cancer such as head and neck squamous cell carcinoma (HNSCC) [1] [2] [3].
In Vivo, Anti-Mouse LAG-3 Antibody (C9B7W) (10 mg/kg, i.p., once every 3 days, for 14-21 days) significantly improves survival rate combined with PD-1 mAb in C57BL/6 mice with head and neck squamous cell carcinoma (HNSCC) induced by Nitrochin [2]. Anti-Mouse LAG-3 Antibody (C9B7W) (10 mg/kg, i.p., on day 7, 10 and 14) exhibits significant anti-tumor activity in female A/J mice bearing SA1N tumors[3].
References:
[1]. Cemerski, S., et al. T cell activation and anti-tumor efficacy of anti-LAG-3 antibodies is independent of LAG-3 – MHCII blocking capacity. j. immunotherapy cancer 3 (Suppl 2), P183 (2015).
[2]. Wang X, et al. Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils. Nat Commun. 2025 Apr 28;16(1):3975.
[3]. Thudium K, et al. Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res. 2022 Oct 4;10(10):1175-1189.
In Vivo, Anti-Mouse LAG-3 Antibody (C9B7W) (10 mg/kg, i.p., once every 3 days, for 14-21 days) significantly improves survival rate combined with PD-1 mAb in C57BL/6 mice with head and neck squamous cell carcinoma (HNSCC) induced by Nitrochin [2]. Anti-Mouse LAG-3 Antibody (C9B7W) (10 mg/kg, i.p., on day 7, 10 and 14) exhibits significant anti-tumor activity in female A/J mice bearing SA1N tumors[3].
References:
[1]. Cemerski, S., et al. T cell activation and anti-tumor efficacy of anti-LAG-3 antibodies is independent of LAG-3 – MHCII blocking capacity. j. immunotherapy cancer 3 (Suppl 2), P183 (2015).
[2]. Wang X, et al. Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils. Nat Commun. 2025 Apr 28;16(1):3975.
[3]. Thudium K, et al. Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res. 2022 Oct 4;10(10):1175-1189.