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Apadoline (Synonyms: Apadoline; RP 60180; RP-60180; RP60180;)

Catalog No.GB62310 Copy One-Click Copy Product Info

Apadoline, also known as RP 60180, is a non-peptidic kappa-opioid receptor agonist.

Products are for research use only. Not for human use. We do not sell to patients.

Apadoline Chemical Structure

Cas No.: 135003-30-4

Size Price Stock Qty
1mg
$150.00
In stock
5mg
$350.00
In stock
10mg
$550.00
In stock
25mg
$950.00
In stock
50mg
$1,650.00
In stock
100mg
$2,950.00
In stock

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Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of Apadoline

Apadoline, also known as RP 60180, is a non-peptidic kappa-opioid receptor agonist. From the dose of 1 mg/kg i.v., RP 60180 slowed ECG frequency. This effect, which lasted for about 30 minutes post-injection, was most often seen at the higher doses. According to literature, both RP 60180 and pentazocine reduced pain-related CSSERP amplitudes by approximately 40%. Pentazocine tended to produce more side effects.

Chemical Properties of Apadoline

Cas No. 135003-30-4 SDF
Synonyms Apadoline; RP 60180; RP-60180; RP60180;
Canonical SMILES O=C(C(C=C1N2[C@H](C)CN3CCCC3)=CC=C1SC4=C2C=CC=C4)NCCC
Formula C23H29N3OS M.Wt 395.565
Solubility Soluble in DMSO Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Apadoline

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.528 mL 12.6401 mL 25.2803 mL
5 mM 505.6 μL 2.528 mL 5.0561 mL
10 mM 252.8 μL 1.264 mL 2.528 mL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution) of Apadoline

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Reviews

Review for Apadoline

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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