Apadoline, also known as RP 60180, is a non-peptidic kappa-opioid receptor agonist. From the dose of 1 mg/kg i.v., RP 60180 slowed ECG frequency. This effect, which lasted for about 30 minutes post-injection, was most often seen at the higher doses. According to literature, both RP 60180 and pentazocine reduced pain-related CSSERP amplitudes by approximately 40%. Pentazocine tended to produce more side effects.
Apadoline
Catalog No.: GB62310Purity:>98%Synonyms: Apadoline; RP 60180; RP-60180; RP60180;
Apadoline, also known as RP 60180, is a non-peptidic kappa-opioid receptor agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 135003-30-4
1mgIn Stock
$150.00
1
5mgIn Stock
$350.00
1
10mgIn Stock
$550.00
1
25mgIn Stock
$950.00
1
50mgIn Stock
$1,650.00
1
100mgIn Stock
$2,950.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 1mg | $150.00 | In Stock | 1 | |
| 5mg | $350.00 | In Stock | 1 | |
| 10mg | $550.00 | In Stock | 1 | |
| 25mg | $950.00 | In Stock | 1 | |
| 50mg | $1,650.00 | In Stock | 1 | |
| 100mg | $2,950.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Chemical Properties
CAS No.
135003-30-4
Synonyms
Apadoline; RP 60180; RP-60180; RP60180;
SMILES
O=C(C(C=C1N2[C@H](C)CN3CCCC3)=CC=C1SC4=C2C=CC=C4)NCCC
Molecular Formula
C23H29N3OS
Molecular Weight
395.565
Solubility
Soluble in DMSO
Storage
Store at-20℃
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
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