2’-Deoxyadenosine-5’-diphosphate (sodium salt)

2’-Deoxyadenosine-5’-diphosphate (dADP) is a purine nucleotide diphosphate.¹ It inhibits the polymerization of ADP and CDP by E. coli or P. fluorescens polynucleotide phosphorylase when used at a concentration of 0.23 mM.² dADP levels are increased in erythrocytes isolated from patients with adenosine deaminase (ADA) deficiency, an inborn error of metabolism characterized by severe combined immunodeficiency (SCID).³

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide biosynthesisBiochemistry(2002) 2.Lucas-Lenard, J.M., and Cohen, S.S.The inhibition of polynucleotide phosphorylase by certain substrate analoguesBiochim. Biophys. Acta123(3)471-477(1966) 3.Coleman, M.S., Donofrio, J., Hutton, J.J., et al.Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiencyJ. Biol. Chem.253(5)1619-1626(1978)