4-Arm-PEG10000-Vinyl sulfone (4-Arm-PEG10000-VS) is a four-armed PEG derivative. The core structure of 4-Arm-PEG10000-Vinyl sulfone consists of four PEG chains, each modified at the end with a vinyl sulfone (Vinyl sulfone) group. 4-Arm-PEG10000-Vinyl sulfone can be used for bioconjugation and drug delivery.
In Vitro, The structure of PEG-Vinyl sulfon comprises two key parts that work synergistically: Vinyl sulfon group: This group can undergo a Michael addition reaction with free thiol groups on peptides and proteins to form a very stable thioether bond. PEG chain: Acting as a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.
In Vitro, The structure of PEG-Vinyl sulfon comprises two key parts that work synergistically: Vinyl sulfon group: This group can undergo a Michael addition reaction with free thiol groups on peptides and proteins to form a very stable thioether bond. PEG chain: Acting as a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.