AA76-lipid (Compound aa76) is a compound with a C-terminal arginine and histidine. AA76-lipid can be used to prepare pancreas-targeted lipid nanoparticles AH-LNP. After assembling with proteins, the increased size of AH-LNP promotes Capsule-filter-mediated selective accumulation in the pancreas and receptor-mediated endocytosis, thereby enhancing pancreas-targeting ability. AA76-lipid enables highly pancreas-selective delivery of mRNA. AA76-lipid can be used in the research of pancreatic cancer [1].
In Vivo, AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in C57BL/6 mice, with over 94.7% of bioluminescence signal localized to the pancreas[1]. AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in rats, rabbits, dogs, and pigs, with nearly 90% of bioluminescence signal localized to the pancreas[1].
References:
[1]. Lei J, et al. Pancreatic-targeted lipid nanoparticles based on organ capsule filtration. Nature. Published online February 25, 2026.
In Vivo, AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in C57BL/6 mice, with over 94.7% of bioluminescence signal localized to the pancreas[1]. AH-LNP (composed of AA76-lipid) (80 μg/kg; i.p.; single dose) delivers mRNA with high pancreatic selectivity in rats, rabbits, dogs, and pigs, with nearly 90% of bioluminescence signal localized to the pancreas[1].
References:
[1]. Lei J, et al. Pancreatic-targeted lipid nanoparticles based on organ capsule filtration. Nature. Published online February 25, 2026.