ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a Ki value of 4.7 μM and an IC50 value of 16 μM. ALDH3A1-IN-3 has no inhibitory potential on the in vitro activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2. ALDH3A1-IN-3 can be used in cellular oxidation and cancer research.
ALDH3A1-IN-3 (CB29) (50 μM, 3 min) significantly inhibits ALDH3A1 activity in A549 and SF767 cells[1].
References:
[1]. Parajuli B,et al. Development of selective inhibitors for human aldede dedrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity. Chembiochem. 2014 Mar 21;15(5):701-12.