Amisometradine is an orally active aminouracil diuretic with a diuretic potency approximately 40% that of Mersalyl (when administered intramuscularly). Amisometradine exerts its effects by promoting the excretion of sodium, chloride and a small amount of potassium, exhibits significant therapeutic effects in heart failure models, and has good tolerance with long-term administration. Compared with drugs of the same class, Amisometradine causes fewer gastrointestinal reactions; its minor side effects mainly include nausea, vomiting, diarrhea, tinnitus and deafness, and are usually not accompanied by proteinuria or abnormalities in blood and urine indicators. Amisometradine is an important tool for the study of heart failure and related diuretic mechanisms [1].
References:
[1]. Jose A D, Wood P. Amisometradine, a new oral diuretic[J]. British Medical Journal, 1958, 1(5061): 9.
References:
[1]. Jose A D, Wood P. Amisometradine, a new oral diuretic[J]. British Medical Journal, 1958, 1(5061): 9.