Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) is an anti-mouse Thy1/CD90 IgG2a monoclonal antibody. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can clear T cells from the spleen and bone marrow. Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) can be used for researches on immunology and inflammation conditions such as colitis [1] [2] [3].
In Vivo, Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) (250 μg, i.p., on days −1, 1 and 4) significantly reduces the severity of colitis in Rag2−/−Il2rg−/− mice[3].
In Vitro, Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) (50 μg/mL, 1 h) can remove T cells combined with 1:20 rabbit complement in antigen-presenting cells (APCs) from the spleen of mice[2].
References:
[1]. Weng X, et al. The adaptor protein SAP regulates type II NKT-cell development, cytokine production, and cytotoxicity against lymphoma. Eur J Immunol. 2014 Dec;44(12):3646-57.
[2]. Jenkins BJ, et al. ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity. bioRxiv [Preprint]. 2025 Mar 19:2025.03.19.643996.
[3]. Vonarbourg C, et al. Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. Immunity. 2010 Nov 24;33(5):736-51.
In Vivo, Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) (250 μg, i.p., on days −1, 1 and 4) significantly reduces the severity of colitis in Rag2−/−Il2rg−/− mice[3].
In Vitro, Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) (50 μg/mL, 1 h) can remove T cells combined with 1:20 rabbit complement in antigen-presenting cells (APCs) from the spleen of mice[2].
References:
[1]. Weng X, et al. The adaptor protein SAP regulates type II NKT-cell development, cytokine production, and cytotoxicity against lymphoma. Eur J Immunol. 2014 Dec;44(12):3646-57.
[2]. Jenkins BJ, et al. ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity. bioRxiv [Preprint]. 2025 Mar 19:2025.03.19.643996.
[3]. Vonarbourg C, et al. Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. Immunity. 2010 Nov 24;33(5):736-51.