Anticancer agent 93 is a 4-droxycoumarin derivative. Anticancer agent 93 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesencmal transition (EMT) effectors.
Anticancer agent 93 (compound 4h) (5-15 μM; 24 h) significantly inhibits A549 cell invasion by ~ 50%[1].Anticancer agent 93 (15 μM; 24-72 h) significantly inhibits A549 cell migration[1].Anticancer agent 93 (5-15 μM; 4 h) inhibits lung cancer cell motility by downregulating EMT markers[1].
References:
[1]. Zhou R, et, al. Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility. Sci Rep. 2022 Dec 14;12(1):21635.