Avermectin B1b (Synonyms: Abamectin B1b, Antibiotic C 076B1b) |
| رقم الكتالوجGC15966 |
An insecticide and anthelmintic
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 65195-56-4
Sample solution is provided at 25 µL, 10mM.
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Avermectins are insecticides and anthelmintics first isolated from broths fermented by S. avermitilis.[1] They potentiate glutamate- and GABA-gated chloride channel opening in nematodes.[2],[3] Avermectin B1b is a minor component of avermectin broth.[2] Avermectins, including avermectin B1b, are used broadly against nematodes, ticks, flies, and ants.[2]
Reference:
[1]. Egerton, J.R., Ostlind, D.A., Blair, L.S., et al. Avermectins, new family of potent anthelmintic agents: Efficacy of the B1a component. Antimicrobial Agents and Chemotherapy 15(3), 372-378 (1979).
[2]. Duke, S.O., Cantrell, C.L., Meepagala, K.M., et al. Natural toxins for use in pest management. Toxins (Basel) 2(8), 1943-1962 (2010).
[3]. Arena, J.P., Liu, K.K., Paress, P.S., et al. The mechanism of action of avermectins in Caenorhabditis elegans: Correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. Journal of Parasitology 81(2), 286-294 (1995).
| Cas No. | 65195-56-4 | SDF | |
| المرادفات | Abamectin B1b, Antibiotic C 076B1b | ||
| Chemical Name | 5-O-demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)-avermectin A1a | ||
| Canonical SMILES | CC([C@](O1)([H])[C@@](C=C[C@@]21C[C@](O3)([H])C[C@@](O2)([H])C/C([H])=C([C@](O[C@@]4([H])C[C@@](OC)([H])[C@](O[C@@]5([H])C[C@@](OC)([H])[C@](O)([H])[C@](O5)([H])C)([H])[C@](O4)([H])C)([H])[C@@](/C([H])=C([H])/C([H])=C([C@@]67O)\CO[C@]7([H])[C@@](O)([H])C( | ||
| Formula | C47H70O14 | M.Wt | 859.05 |
| الذوبان | Soluble in ethanol, or in methanol, or in DMSO, or in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1641 mL | 5.8204 mL | 11.6408 mL |
| 5 mM | 232.8 μL | 1.1641 mL | 2.3282 mL |
| 10 mM | 116.4 μL | 582 μL | 1.1641 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >85.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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