AZD4635 (Synonyms: HTL-1071, Imaradenant) |
| رقم الكتالوجGC19049 |
AZD4635 (HTL1071) هو أحد مضادات مستقبلات الأدينوزين A2A القوية والانتقائية والنشطة عن طريق الفم (A2AR). AZD4635 يرتبط بـ A2AR البشري بـ Ki 1.7 نانومتر ويظهر أكثر من 30 ضعفًا انتقائية على مستقبلات الأدينوزين الأخرى.
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Cas No.: 1321514-06-0
Sample solution is provided at 25 µL, 10mM.
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AZD4635 is a potent and selective, orally available adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors[1].
In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively[1].
References:
[1]. Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.
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