Azide-PEG20000-azide is a PEG derivative. It is a click chemistry reagent. Containing the Azide group, it can undergo a copper-catalyzed azido-azynylene cycloaddition reaction (CuAAc) with molecules containing the Alkyne group. It can also undergo a ring-strain-driven alkyne-azido cycloaddition reaction (SPAAC) with molecules containing the DBCO or BCN groups.
References:
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
References:
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562