β-Epoxysitosterol is an Estrogen receptor α agonist. β-Epoxysitosterol accumulates in the plasma, aorta, liver, kidney and heart of hamsters fed with diets containing phytosterol oxidation products. β-Epoxysitosterol can be used in the research of liver cancer [1] [2].
In Vitro, β-Epoxysitosterol (10 μM) induces luciferase activity, a marker of estrogen receptor α activation, in estrogen receptor α-transfected HeLa cells[1]. β-Epoxysitosterol (120 μM; 24 h) reduces the viability of HepG2 cells to 73%[2].
References:
[1]. Ryan E, et al. Phytosterol oxidation products: their formation, occurrence, and biological effects[J]. Food Reviews International, 2009, 25(2): 157-174.
[2]. Takayasu BS, et al. Biological effects of an oxyphytosterol generated by β-Sitosterol ozonization. Archives of biochemistry and biophysics. 2020 Dec 15;696:108654.
In Vitro, β-Epoxysitosterol (10 μM) induces luciferase activity, a marker of estrogen receptor α activation, in estrogen receptor α-transfected HeLa cells[1]. β-Epoxysitosterol (120 μM; 24 h) reduces the viability of HepG2 cells to 73%[2].
References:
[1]. Ryan E, et al. Phytosterol oxidation products: their formation, occurrence, and biological effects[J]. Food Reviews International, 2009, 25(2): 157-174.
[2]. Takayasu BS, et al. Biological effects of an oxyphytosterol generated by β-Sitosterol ozonization. Archives of biochemistry and biophysics. 2020 Dec 15;696:108654.