BCI hydrochloride (Synonyms: (E)-BCI hydrochloride) |
| رقم الكتالوجGC65025 |
هيدروكلوريد BCI ((E) -BCI) هو مثبط DUSP6 (فوسفاتيز 6 مزدوج الخصوصية)
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Cas No.: 95130-23-7
Sample solution is provided at 25 µL, 10mM.
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BCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI hydrochloride specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI hydrochloride does not inhibit DUSP5[1].
[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.
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