BD-Oligo is an oligomer-specific fluorescent chemical probe. BD-Oligo preferentially identifies Aβ oligomer assemblies over monomers or fibrils by using diversity-directed fluorescent library (DOFL) screening and computational techniques. BD-Oligo exhibits dynamic oligomer monitoring capabilities during Aβ peptide fibril formation as Aβ is induced to form oligomers and ultimately fibrils over time. BD-Oligo also exhibits blood-brain barrier permeability with the ability to stain Aβ oligomers in vivo [1].
References:
[1]. Teoh CL, et al. Chemical Fluorescent Probe for Detection of Aβ Oligomers. J Am Chem Soc. 2015 Oct 28;137(42):13503-9.
References:
[1]. Teoh CL, et al. Chemical Fluorescent Probe for Detection of Aβ Oligomers. J Am Chem Soc. 2015 Oct 28;137(42):13503-9.