CBR-470-2 |
| رقم الكتالوجGC61636 |
يمكن لـ CBR-470-2 ، وهو نظير مستبدل بالجليسين ، تنشيط إشارات NRF2
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Cas No.: 2416095-00-4
Sample solution is provided at 25 µL, 10mM.
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CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis[1].
CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].
CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1]. Animal Model: Balb/C mice (5-week old) are exposed to UVB[1]
[1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604.
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