Cemtirestat (CMTI) is a carboxymethylated thiatriazinoindole inhibitor of aldose reductase ( ALR2 ). Cemtirestat potently inhibits rat ocular lens ALR2 with an IC50 of 0.116 μM, and exhibits a 302-fold selectivity for rat kidney ALR1. Cemtirestat is applicable to the research of advanced diabetic complications [1].
References:
[1]. Hlaváč M, et al. Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket. Bioorg Med Chem. 2021;29:115885.
References:
[1]. Hlaváč M, et al. Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket. Bioorg Med Chem. 2021;29:115885.