CHD1L-IN-2 is a CHD1L inhibitor and exhibits cytotoxicity against tumor cells [1] [2].
In Vitro, CHD1L-IN-2 (Compound 6.3) (72 h) has IC50 values of 3.6 and 3.7 μM for SW620 and HCT116 cells[1].
References:
[1]. Daniel V. LABARBERA, et al. Small molecule inhibitors of oncogenic chd1l with preclinical activity against colorectral cancer. WO2023055763A2. 2023-04-06.
[2]. Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022 Mar 10;65(5):3943-3961.
In Vitro, CHD1L-IN-2 (Compound 6.3) (72 h) has IC50 values of 3.6 and 3.7 μM for SW620 and HCT116 cells[1].
References:
[1]. Daniel V. LABARBERA, et al. Small molecule inhibitors of oncogenic chd1l with preclinical activity against colorectral cancer. WO2023055763A2. 2023-04-06.
[2]. Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022 Mar 10;65(5):3943-3961.