CN128 (Synonyms: R-CN128) |
| رقم الكتالوجGC60719 |
CN128 (CN328) عبارة عن مخلب حديد انتقائي نشط عن طريق الفم.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1335282-05-7
Sample solution is provided at 25 µL, 10mM.
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CN128 is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].
CN128 possesses a high selectivity for iron(III) over others metals[1].
CN128 (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].The iron removal efficacies of CN128 displays a dose-dependent behavior[1].CN128 lacks genetic toxicity[1].CN128 (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].CN128 is well-tolerated, with no mortality being observed at the higher dose levels in rats[1]. Animal Model: Male SD rats (300 g)[1]
[1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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