GLPBio

CORM-3

Catalog No.: GC18071Purity:>98.00%
COASDSData Sheet

يعرض تأثيرات مضادة للالتهابات / حماية القلب.

المنتجات مخصصة للاستخدام البحثي فقط، وليست للاستخدام البشري. نحن لا نبيع للمرضى.

CORM-3
Cas No.: 475473-26-8
20mgIn Stock
$81.00
1
50mgIn Stock
$159.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

المراجع (Citations)

لا تتوفر حاليًا مراجع لهذا المنتج. فيما يلي مجموعة مختارة من المنشورات التي تستشهد بمنتجات GlpBio.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

الوصف (Description)

CORM-3 is a water soluble CO-releasing molecule, uncouples mitochondrial respiration via interaction with the phosphate carrier. It can reduce the nuclear heterotopic of NF-κB p65, reduce the production of ROS, and increase the levels of glutathione and superoxide dismutase in cells. Besides, CORM-3 reduces the activation of NLRP3 inflammasome [1-3].

CORM-3(0-400 μM; 2 hours) inhibited the effect of H2O2 on the viability of BMSCs in a dose-dependent manner. CORM-3 could reduce reactive oxygen species (ROS) accumulation and prevent mitochondrial dysfunction thereby restoring the osteogenic potential of the BMSCs disrupted by hydrogen peroxide (H2O2) exposure[4]. CORM-3(20 μM ;30 min) induces DNA damage through Ru(II) binding to DNA[5].

CORM-3(4 mg/kg; i.v) mitigated HSR-induced intestinal damages[6]. CORM-3 could effectively improve the inflammatory response induced by activation of the microglia (MG), reduce neuronal apoptosis, promote neural regeneration, and improve the learning and memory performance of mice after radiation[7].

References:

[1]. Long R, Salouage I, Berdeaux A, et,al. CORM-3, a water soluble CO-releasing molecule, uncouples mitochondrial respiration via interaction with the phosphate carrier. Biochim Biophys Acta. 2014 Jan;1837(1):201-9. doi: 10.1016/j.bbabio.2013.10.002. Epub 2013 Oct 23. PMID: 24161358.

[2]. Huang Y, Ma T, et,al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39. doi: 10.1016/j.exer.2017.08.016. Epub 2017 Oct 16. PMID: 29051011.

[3]. Lee DW, Shin HY, et,al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963. doi: 10.1016/j.bbrc.2017.09.111. Epub 2017 Sep 21. PMID: 28942141.

[4]. Jin C, Lin BH, et,al. CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2022 Aug 17;2022:5098358. doi: 10.1155/2022/5098358. PMID: 36035220; PMCID: PMC9402314.

[5]. Lyon RF, Southam HM, et,al. CORM-3 induces DNA damage through Ru(II) binding to DNA. Biochem J. 2022 Jul 15;479(13):1429-1439. doi: 10.1042/BCJ20220254. PMID: 35726678; PMCID: PMC9342897.

[6]. Zhang LM, Xin Y, et,al. CORM-3 alleviates the intestinal injury in a rodent model of hemorrhage shock and resuscitation: roles of GFAP-positive glia. J Mol Histol. 2023 Aug;54(4):271-282. doi: 10.1007/s10735-023-10133-w. Epub 2023 Jun 19. PMID: 37335421.

[7]. Lu K, Wu WJ, et,al. CORM-3 Regulates Microglia Activity, Prevents Neuronal Injury, and Improves Memory Function During Radiation-induced Brain Injury. Curr Neurovasc Res. 2020;17(4):464-470. doi: 10.2174/1567202617999200730213259. PMID: 32748746.

البروتوكول (Protocol)

Cell experiment [1]:

Cell lines

BMSCs (Sprague-Dawley rats)

Preparation method

Cells were inoculated in 96-well plates at a density of and treated for 2 hours with varying CORM-3 concentrations (0, 12.5, 25, 50, 100, 200, and 400 μM) with or without H2O2 treatment.

Reaction Conditions

0, 12.5, 25, 50, 100, 200, and 400 μM; 2 hours

Applications

CORM-3 inhibited the effect of H2O2 on the viability of BMSCs in a dose-dependent manner.

Animal experiment [2]:

Animal models

Male SD rats (Hemorrhagic shock and resuscitation (HSR)model)

Preparation method

HSR rat were intravenously administered with CORM-3. At 24 h and 7 d after HSR modeling, the pathological changes in intestinal tissues were evaluated.

Dosage form

4 mg/kg; i.v

Applications

CORM-3 mitigated HSR-induced intestinal damages.

References:

[1].Jin C, Lin BH, et,al. CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2022 Aug 17;2022:5098358. doi: 10.1155/2022/5098358. PMID: 36035220; PMCID: PMC9402314.

[2]. Zhang LM, Xin Y, et,al. CORM-3 alleviates the intestinal injury in a rodent model of hemorrhage shock and resuscitation: roles of GFAP-positive glia. J Mol Histol. 2023 Aug;54(4):271-282. doi: 10.1007/s10735-023-10133-w. Epub 2023 Jun 19. PMID: 37335421.

وثائق المنتج (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

الخصائص الكيميائية (Chemical Properties)

رقم CAS
475473-26-8
SMILES
O=C1[O-][Ru+2]([Cl-])([C]=O)([C]=O)([C]=O)[NH2]C1
الصيغة الجزيئية
C5H4ClNO5Ru
الوزن الجزيئي
294.61
الذوبانية
DMSO : 100 mg/mL; Water : 50 mg/mL
التخزين
Store at -20°C
إرشادات عامة
اختر مذيبًا مناسبًا وفقًا لبيانات ذوبانية المنتج. بعد التحضير، قسّم المحلول المخزون إلى أجزاء لتجنب دورات التجميد والذوبان المتكررة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
شروط الشحن
تُشحن عينات التقييم مع عبوات تبريد. وتُشحن الأحجام الأخرى المتاحة في درجة حرارة الغرفة، أو مع عبوات تبريد عند الطلب.

الحاسبات (Calculators)المولارية / التخفيف / الوزن الجزيئي / تحويل الوحدات / تركيبة داخل الجسم الحي / الذوبانية

g/mol

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