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CpdA (Synonyms: Compound A)

رقم الكتالوجGC18258 Copy One-Click Copy Product Info

CPDA عبارة عن مثبط قوي جديد يحتوي على مجال SH2 يحتوي على inositol phosphatase 2 (SHIP2)

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CpdA التركيب الكيميائي

Cas No.: 14593-25-0

الحجم السعر المخزون الكميّة
10mg
76٫00
متوفر
25mg
176٫00
متوفر
50mg
336٫00
متوفر
100mg
594٫00
متوفر

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مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of CpdA

CpdA is a non-steroidal selective glucocorticoid receptor modulator. It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus. It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF-κB and subsequent cytokines through transrepression. Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone that were either higher (4-fold, IC50 = 6.4 nM and 25.9 nM, respectively, in L929sA cells) or lower (63-fold, Kd = 81.8 nM and 1.29 nM, respectively, in BWTG3 cells) in whole cell binding assays.

Chemical Properties of CpdA

Cas No. 14593-25-0 SDF
المرادفات Compound A
Chemical Name 4-[1-chloro-2-(methylamino)ethyl]-phenol 1-acetate, monohydrochloride
Canonical SMILES CC(OC1=CC=C(C(Cl)CNC)C=C1)=O.Cl
Formula C11H14ClNO2.HCl M.Wt 264.1
الذوبان DMF: 5 mg/ml,DMSO: 25 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CpdA

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.7864 mL 18.9322 mL 37.8644 mL
5 mM 757.3 μL 3.7864 mL 7.5729 mL
10 mM 378.6 μL 1.8932 mL 3.7864 mL
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In vivo Formulation Calculator (Clear solution) of CpdA

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 37 reference(s) in Google Scholar.)

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