D-Glutamic acid-d5 is intended for use as an internal standard for the quantification of D-glutamic acid by GC- or LC-MS. D-glutamic acid is an amino acid and a component of bacterial peptidoglycan.1 It is linked to UDP-N-acetylmuramoyl-L-alanine (UDP-MurNAc-L-Ala) by the muramyl ligase MurD to form UDP-MurNAc-L-Ala-D-glutamic acid, a building block in the biosynthesis of bacterial peptidoglycan. D-glutamic acid is also a component of poly-γ-glutamic acid, a polymer produced by Bacillus.2
1.Kouidmi, I., Levesque, R.C., and Paradis-Bleau, C.The biology of Mur ligases as an antibacterial targetMol. Microbiol.94(2)242-253(2014) 2.Ogasawara, Y., Shigematsu, M., Sato, S., et al.Involvement of peptide epimerization in poly-γ-glutamic acid biosynthesisOrg. Lett.21(11)3972-3975(2019)