Dihydromyrcenol is an orally active flavor ingredient and Antifungal agent. Dihydromyrcenol acts as a toxicant. Dihydromyrcenol induces phototoxicity-related growth inhibition in Bakers' Yeast. In pregnant rats, Dihydromyrcenol causes threshold maternal toxicity by reducing feed consumption and body weight gain, and also induces threshold developmental toxicity by decreasing fetal body weight, inhibiting ossification of metatarsal bones in the hind paws, increasing the number of extra thoracic vertebrae ribs, and altering vertebral counts [1] [2].
In Vivo, Dihydromyrcenol (oral administration; single dose) has an acute oral LD50 of 4.1 g/kg in rats, and dose-dependent mortality and specific toxic symptoms are observed at doses ≥2.56 g/kg[1]. The acute dermal LD50 of single-dose Dihydromyrcenol in rabbits is greater than 5.0 g/kg, and mortality and skin irritation are observed at the tested dose[1]. Undiluted dihydromyrcenol (0.5 mL; topical application) induces skin irritation in New Zealand white rabbits, with average erythema and edema scores of 2.0 and 1.6 at 24-72 h, respectively, and partial resolution by day 7[1].
In Vitro, Dihydromyrcenol (0.1-10%) induces growth inhibition related to phototoxicity in Bakers' Yeast at a concentration of 10%, but exerts no such effect at concentrations of 0.1% or 1.0%[1].
References:
[1]. McGinty D, et al. Fragrance material review on dihydromyrcenol. Food Chem Toxicol. 2010;48 Suppl 3:S70-S75.
[2]. Politano VT, et al. Evaluation of the developmental toxicity of dihydromyrcenol in rats. Int J Toxicol. 2009;28(2):80-87.
In Vivo, Dihydromyrcenol (oral administration; single dose) has an acute oral LD50 of 4.1 g/kg in rats, and dose-dependent mortality and specific toxic symptoms are observed at doses ≥2.56 g/kg[1]. The acute dermal LD50 of single-dose Dihydromyrcenol in rabbits is greater than 5.0 g/kg, and mortality and skin irritation are observed at the tested dose[1]. Undiluted dihydromyrcenol (0.5 mL; topical application) induces skin irritation in New Zealand white rabbits, with average erythema and edema scores of 2.0 and 1.6 at 24-72 h, respectively, and partial resolution by day 7[1].
In Vitro, Dihydromyrcenol (0.1-10%) induces growth inhibition related to phototoxicity in Bakers' Yeast at a concentration of 10%, but exerts no such effect at concentrations of 0.1% or 1.0%[1].
References:
[1]. McGinty D, et al. Fragrance material review on dihydromyrcenol. Food Chem Toxicol. 2010;48 Suppl 3:S70-S75.
[2]. Politano VT, et al. Evaluation of the developmental toxicity of dihydromyrcenol in rats. Int J Toxicol. 2009;28(2):80-87.