DIM |
| رقم الكتالوجGC50061 |
Inhibits EGFR activation; also induces apoptosis
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1968/5/4
Sample solution is provided at 25 µL, 10mM.
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Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24 PMID:22205686 |Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297 PMID:20444961 |Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975 PMID:22514694
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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